Letrozol Teva Filmtabletten 2.5mg 100 Stück

23,95 239,57 

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The apparent elimination half-life from blood plasma is about 2-4 days. The equilibrium concentration is reached within 2-6 weeks of daily administration of a daily dose of 2.5 mg. Some non-linearity of pharmacokinetics at daily administration of letrozole in the dose of 2.5 mg is noted, because the plasma concentration in the equilibrium state is about 7 times higher than the concentration measured after a single dose of 2.5 mg (the expected concentration in the equilibrium state is 1.5-2 times higher than after a single dose of 2.5 mg). Since the plasma concentration at the equilibrium state remains stable over time, it can be concluded that there is no prolonged cumulation of letrozole.


Pharmacokinetics were dose-proportional after single oral administration of letrozole in doses up to 10 mg (0.01 to 30 mg) and after daily administration in doses up to 1.0 mg (0.1 to 5 mg). After a single oral administration of the drug at a dose of 30 mg, a slight dose-proportional increase in the AUC value was observed. At daily doses of 2.5 mg and 5 mg, the AUC value increased 3.8-fold and 12-fold against the expected increase of 2.5-fold and 5-fold, respectively, compared with administration at a dose of 1 mg daily. Thus, the recommended dose of 2.5 mg is a borderline dose above which disproportionate overdosing becomes evident, and this phenomenon was more pronounced at the 5 mg dose. The disproportionate exceeding of dose proportionality is probably the result of saturation of metabolic clearance processes. Equilibrium values were reached 1-2 months after administration at different doses.

Additional information

substance active


Amount of substance, mg


formulaire de discharge


1 compressed, mg


Plaquettes thermoformed by package, pieces



Teva Industries pharmaceutics

volume de commande

1 blister of 10 compresses, 1 pack (3 blisters), 1 package (10 blisters)


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